GP antibiotic overuse and microbial resistance

Antibiotic overuse: a key driver of antimicrobial resistance.

Overuse of Antibiotics and Antibiotic Resistance in Medical Applications Featuring Carbapenemase Resistant Enterobacteriaceae (CRE)

The decreasing effectiveness of antibiotics in treating common infections results from the spread of antimicrobial resistance (AMR), and is building up to become an epic global public health crisis. Extended periods of antibiotic overuse and misuse since their introduction have applied strong selective pressure towards high-level AMR and Multiple Drug Resistance (MDR), rendering entire classes ...

Mechanisms of Antibiotic Resistance in the Microbial World

EHRLICH was followed by Alexander FLEMING, who discovered penicillin by accident in 1928. Then, in the 1935, Gerhard DOMAGK discovered the sulfa drugs, thereby paving the way to the discovery of the anti-TB drug Isoniazid. Then, in 1939, René DUBOS became the first scientist to discover an antibiotic after purposely looking for it in soil microbes. DUBOS discovered Gramicidin, which is still us...

Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation

The structure and composition of bacterial communities can compromise antibiotic efficacy. For example, the secretion of β-lactamase by individual bacteria provides passive resistance for all residents within a polymicrobial environment. Here, we uncover that collective resistance can also develop via intracellular antibiotic deactivation. Real-time luminescence measurements and single-cell ana...

Antibiotic use and overuse for appendicectomy in Antigua and Barbuda.

The use of antibiotics for appendicectomy in Antigua and Barbuda, from January 1998 to December 1999, was examined with respect to current Surgical Infection Society guidelines from developed countries. There were 143 cases of appendicectomy performed at Holberton Hospital. The mean patient age and standard deviation (SD) was 28.1 +/- 15.8 years, 57% female. Pathology showed inflammed appendix ...